[pg 20]
CHAPTER IV
CAUSES OF EPILEPSY
"Find out the cause of this effect,
Or rather say, the cause of this defect,
For this effect defective comes by cause."
"Hamlet," Act II.
THE MECHANISM OF THE FIT
The brain consists of cells of grey matter, grouped together to form centres for thought, action or sensation, and white matter,
consisting of nerve strands, which act as lines of communication between
different parts of brain and body. The wrinkled surface (cortex)
of the brain, is covered with grey matter, which dips into the fissures.
There are also islands of grey matter embedded in the white.
The front part of the brain is supposed, with some probability, to be the seat of intelligence, while a ribbon three inches wide stretched over
the head from ear to ear would roughly cover the Rolandic area, in which
we find the motor cells through which impulse is translated
to action. These motor cells are controlled by inhibitory cells,
which act as brakes and release nerve energy in a gentle stream;
otherwise our movements would be convulsive in their violence, and life
would be impossible through inability usefully to direct our energy.
That is how inhibition acts physically; mentally it is the power to restrain impulses until reason has suggested the wisest course.
[pg 21]
Irritation of the cortex, especially the motor area, causes
convulsions, and experiment has shown that epilepsy may be due to a
disease or instability of certain inhibitory cells of the cortex. The
motor cells of epileptics are restrained, with some difficulty, by these
cells in normal times. When irritation from any cause throws additional
strain on the motor cells, the defective brakes fail, and the
uncontrolled energy, instead of flowing in a gentle stream through the
usual channels, bursts forth in a tidal wave through other areas of the
brain, causes unconsciousness, and exhausts itself in those violent
convulsions of the limbs which we term a fit.
The Primary Cause of epilepsy is an inherent instability of the nervous system.
Secondary Causes are factors which cause the first fit in a person with predisposing nervous instability; later, the brain gets the fit habit, and attacks recur independently of the secondary cause. In most cases no secondary causes can be discovered, and the disease is then termed idiopathic, for want of an explanation.
Injuries to the brain may cause epilepsy, and many cases date from
birth, a difficult labour having caused a minute injury to the brain.
Some accident is often wrongly alleged as the cause of fits, for most
victims come of a bad stock, and when the first fit occurs, their
relatives recollect an injury or a fright in the past, which is said to
be the cause.
Great fright may cause epilepsy, as in the case of a nervous girl
whose brother entered her room, covered with a sheet, as a "ghost", a
"joke" that was followed by a fit within an hour.
Sunstroke may cause fits, and a few cases follow infectious
diseases.
Alcoholism is a strong secondary factor, fits often [pg 22] occurring
during a drinking-bout and in topers, but in many cases, drunkenness,
instead of being the cause, is only the result of a lack of self-control
following epilepsy.
Pregnancy may be a secondary cause of the malady: it may lead to more
frequent and severe seizures in women who are already victims; bring on a
recurrence of the malady after it has apparently been cured; or, very
rarely, induce a temporary or permanent cure.
Epilepsy may be due to abortives. These drugs wreck the constitution
of the undesired children, who contract epilepsy from causes which would
not so have affected them had they started fairly. In many families, the
first child, who was wanted, is normal; some or all the others, who were
not desired and on whom attempts were probably made to prevent birth, are
neuropaths, as are many illegitimate children. It cannot too emphatically
be stated that there is no drug known which will procure abortion without
putting the woman's life in so grave a danger as to prevent medical men
using it; legal abortion is always procured surgically. Dealing in
abortifacients would be a capital offence under the laws of a rational community.
Self-abuse [masturbation] may perhaps play some part in epilepsy commencing or recurring after the age of ten.
The onset of menstruation often coincides with the onset of epilepsy, and in some cases irregularity of the menses seems to be a secondary or exciting cause.
Exciting Causes aggravate the trouble when present, causing
more frequent and severe seizures. The chief are irritation of stomach
and bowels (from decaying teeth, unchewed, unsuitable, or indigestible
food, constipation, or diarrhea), exhaustion, work immediately after
a meal, passion or excitement, fright, [pg 23] worry, mental work,
alcoholism, sexual excess, nasal growths, eye-strain; in short, anything
that irritates brain or body.
Theories as to Cause. Epilepsy is usually classed as a
functional disorder; that is, the brain cells are physically
normal, but, for some unknown reason, they act abnormally at certain
times. This term is a very loose one, and there is reason to believe that
the basis of epilepsy is some obscure disease of the brain which has not
been detected by present methods.
The new school of psychologists regard the malady as a mental
complex—a system of ideas strongly influenced by the
emotions—the convulsions being but minor symptoms.
Fits are most frequent between 9-10 p.m. the hours of deepest repose. One school says this is due to anĉmia of the brain during sleep. Clark [Possibly Leon Pierce Clark, 1870-1953] traces the cause to lessened inhibitory powers owing to the higher brain centres being at rest, while [Alexander] Haig, 1853-1924, claims to have explained the high incidence at this hour by the fact that uric acid is present in the system in the greatest amount at this time.
Some doctors have thought, on the contrary, that excess of
blood in the head was the cause, but results of treatment so directed did
not bear out the sanguine hopes built on the theory.
The fact that convulsions occur in diabetes and alcoholism, suggested
that epilepsy was due to poisons circulating in the blood, and thus
irritating the brain. Every act uses up cell material and leaves waste
products, exactly as the production of steam uses up coal and leaves
ashes. Various waste products have been found in more than normal
quantities in the blood of epileptics, but it is uncertain whether
accumulation of waste products causes the seizure.
A convincing theory must satisfactorily account for [pg 24] all the
widely diverse phenomena seen in epilepsy, and the problem must remain
largely a matter of speculation, until research work has given us a far deeper insight into the biochemistry of both the brain cells, and the germ-plasm than we have at present.